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mouse kidney epithelial cell line  (ATCC)


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    ATCC mouse kidney epithelial cell line
    The mechanism diagram of the study. Upregulated ATF3 in damaged tubular <t>epithelial</t> cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.
    Mouse Kidney Epithelial Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 209 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+kidney+epithelial+cell+line/TCMK-1/pmc12781174-59-0-20
    Average 96 stars, based on 209 article reviews
    mouse kidney epithelial cell line - by Bioz Stars, 2026-09
    96/100 stars

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    1) Product Images from "ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming"

    Article Title: ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming

    Journal: International Journal of Biological Sciences

    doi: 10.7150/ijbs.125062

    The mechanism diagram of the study. Upregulated ATF3 in damaged tubular epithelial cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.
    Figure Legend Snippet: The mechanism diagram of the study. Upregulated ATF3 in damaged tubular epithelial cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.

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    Related Articles

    Cell Culture:

    Article Title: WTAP-mediated N 6 -methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy
    Article Snippet: .. Human renal tubular epithelial HK-2 cells and mouse kidney epithelial cell line (TCMK-1) were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA) and cultured in Dulbecco’s modified Eagle medium (DMEM; Gibco, USA; 10564029) with 10% fetal bovine serum (Gibco; 16000044) and 100 U/mL penicillin and streptomycin (Solarbio, Beijing, China; P1400-100). ..

    Article Title: Discovery of indol-6-yl-pyrrolo[2,3-c]pyridin-7-one derivatives as bromodomain-containing protein 4 (BRD4) inhibitors for the treatment of kidney fibrosis.
    Article Snippet: Uncovering new therapeutics for kidney fibrosis hold promise for chronic kidney disease (CKD).. Considerable studies confirmed that BRD4 inhibition ameliorated kidney injury and fibrosis.. In the study, we synthesized a series of indol-6-yl-pyrrolo[2,3-c]pyridin-7-one derivatives and biologically evaluated against BRD4 for structure-activity relationship (SAR).

    Article Title: ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming
    Article Snippet: .. Mouse kidney epithelial cell line (TCMK-1), HEK 293T cells and rat renal interstitial fibroblasts (NRK-49F) cells were purchased from the American Type Culture Collection (Manassas, VA) and were cultured in DMEM (Sigma-Aldrich) containing 10% fetal bovine serum (FBS), at 37°C, 5% CO2, 95% air. .. Cells were starved with 0.5% FBS (SH30084.03, Hyclone, Beijing, China) for 24 h, then further treated with 20 ng/mL of TGF-β1 (R&D Systems, 240-B-002/CF, Minneapolis, MN, USA).

    Modification:

    Article Title: WTAP-mediated N 6 -methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy
    Article Snippet: .. Human renal tubular epithelial HK-2 cells and mouse kidney epithelial cell line (TCMK-1) were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA) and cultured in Dulbecco’s modified Eagle medium (DMEM; Gibco, USA; 10564029) with 10% fetal bovine serum (Gibco; 16000044) and 100 U/mL penicillin and streptomycin (Solarbio, Beijing, China; P1400-100). ..



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    The mechanism diagram of the study. Upregulated ATF3 in damaged tubular epithelial cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.

    Journal: International Journal of Biological Sciences

    Article Title: ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming

    doi: 10.7150/ijbs.125062

    Figure Lengend Snippet: The mechanism diagram of the study. Upregulated ATF3 in damaged tubular epithelial cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.

    Article Snippet: Mouse kidney epithelial cell line (TCMK-1), HEK 293T cells and rat renal interstitial fibroblasts (NRK-49F) cells were purchased from the American Type Culture Collection (Manassas, VA) and were cultured in DMEM (Sigma-Aldrich) containing 10% fetal bovine serum (FBS), at 37°C, 5% CO2, 95% air.

    Techniques: